Protein Details: Glutamate receptor-interacting protein 2

Protein ID

ICDB_Pro_0067

Protein Name

Glutamate receptor-interacting protein 2

Gene Name

grip2; grip2.1

Organism

Xenopus laevis (African clawed frog)

Length

1083 amino acids

AlphaFoldDB

AF-A8E0R9-F1-model_v4.pdb

Function

Plays an important role in primordial germ cell (PGC) maintenance and efficiency of PGC migration.

Sequence

MHFFQTILRWKTAKGQKSVTFKKDDGPYSKGNKDPAGNDLALVSRRQSIPEEFRGVTIVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDQLNIGDYIKSVNGINLTKLRHEEIISLLKNVGERVVLEVEYELPPGTPDNSSAIIPKTIEITLCKEGNSFGFVMRGGAHEDWHKSRALVVTYVRPGGPADREGTLKVGDRLLCVDGISLHNITHTDALSILRQCSQEGVFQIEYDVALMDTVTNASGPLLVEIAKTPGSTLGISLSTGTHRNKQVIVIDKVKPASVVDRCGALHPGDHILSIDGTSTEHCTQMEATQLLASIIENVKLEILPAHHSRLPLRPPETVKVQKSDHHHCWDPCVNYCHTPHPGHCKTPTWNPTSNQDYCKSLVAANFSSSSVAGTPGFSSQNSNTLPRTVHPMSPRTTMNRRRQKRKDHKSSLSLASSTVGPGGQIIHTESTEIILRGDPLNGFGIQLQGGIFATETLSSPPLIRFIEPDSPAERCGLLQVGDRLLSINGILTEDGTLEEANQLLRDAALSNKVALEIEFDVAESVVPSSGTFHVKLPKRKGVELGITISSSRKPGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCSMEDAVQILRQCEDLVKLKIRKDEDNSDEQETSGAIIYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHIGDRILAINNISLKGKPLSEAIHLLQMAGETVTLKIKKQTERIFPQRLSDSMNEGSDPEDDLTDSQKTSKLSEIYSTTVPSVDSALESWDGSGIDAGYGSQGTYVPQAVGISLHPHEWRTSRQKSNTPPVEHRKSYPFLDGSFNEQDWEKPTRYPSQPNGLETDHDDSFWRVFGEALEDLETCGQSELLREIEASIMTGSVQDLGLDSSQILLENSSQGGHVLFRRGSHHISSNSPKKENKLSQDARSKKEEVHNAQSLTTELLKVTVQKDMDTDDFGFSVSDGLLEKGVYVNMIRPGGPADRSGLKTYDQILQVNHVRTRDFDCCLTVPLLSDAGDRLDLVISRGLSIKAEEMGVEQIKGPLRMETQTSTKTL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Enriched in the mitochondrial cloud of stage I oocytes; before becoming concentrated at the tip of the vegetal cortex in stage II oocytes. Expression becomes localized to the germ plasm of stage III-IV oocytes and early cleavage stages. At the tailbud stage; localizes to the migrating primordial germ cells (PGCs) until PGC migration is complete (stage 40); at which point. In the adult; expressed in the brain; ovary; eye; muscle; spinal cord and very weakly in adipocytes expression disappears

DOI ID

10.1016/j.bbrc.2007.02.059; 10.1016/j.ydbio.2007.09.012; 10.1111/j.1432-0436.2007.00229.x

RefSeq

NP_001091382.1